Despite being the psychotic disorder archetype, schizophrenia prognosis is paradoxically not based on successful psychosis treatment but on the persistence of the negative and cognitive symptoms, which are still poorly understood. Negative symptoms refer to the lessening or absence of normal behaviours and functions and tandem with the so-called positive symptoms to operationally define schizophrenia diagnosis. This symposium presents novel conceptualisation and pathophysiology of the negative symptoms. Dr Fernandez-Egea will review the history of the concept of the negative symptoms and how it aligns with the terminology in other brain disorders (e.g. apathy vs avolition) by presenting the Characterising Apathy in Schizophrenia: A European Study (CASES), an international effort to validate novel tools to define motivation trans-nosologically. Dr Saleh will then present the CHAPAS study (CHaracterising APAthy in Schizophrenia), which explored motivation in schizophrenia using an effort task, and how this compares to other psychiatric and neurological disorders. Finally, Dr Wolpe will present the results of the CHANSS (CHAracterising Negative Symptoms in Schizophrenia) study, which explores what factors specifically contribute to decreased motivation in schizophrenia and how to treat them.
Chair: Professor Peter Jones, Department of Psychiatry, University of Cambridge
Shall we reconsider the term negative symptoms? - Dr Emilio Fernandez-Egea, Department of Psychiatry, University of Cambridge
Characterising apathy in schizophrenia - Youssuf Saleh, Department of Neurology, University of Oxford
The mechanisms of motivation deficits in schizophrenia - Dr Noham Wolpe, University of Tel-Aviv and University of Cambridge