Metabolic syndrome and schizophrenia

The World Health Organization (WHO) has recognised metabolic syndrome as a global epidemic (Potenza & Mechanick, 2009). Its causes are not fully understood but its consequences can be severe, including type 2 diabetes mellitus and cardiovascular disease.

Contributory factors include an unhealthy diet, smoking, genetics, lack of exercise and excess alcohol. It is a common comorbidity in people with schizophrenia and some antipsychotics may worsen the risks.

Appropriate interventions can reduce the risk of mortality and morbidity. In recent years the clinical focus has shifted towards early algorithmic intervention. These incorporate the INTEGRATE guidelines (McCutcheon et al, 2025) and updated Lester Resource protocols (Perry et al, 2023).

This module will offer a framework to help with the diagnosis of metabolic syndrome and will advise on appropriate interventions for patients at risk. It will answer the following questions:

• What is metabolic syndrome and how is it diagnosed?
• What is the link between schizophrenia and metabolic syndrome?
• What is the relationship between antipsychotics and metabolic syndrome?
• Why is it difficult to manage patients with both schizophrenia and metabolic syndrome?

Availability

This module is available as part of a CPD eLearning subscription.