Rare genetic mutations are associated with high likelihood of mental and physical health conditions throughout the lifespan

Our clinical studies of children and young people with a range of rare genetic variants indicate 80% have psychiatric conditions and that learning disability, motor coordination and sleep difficulties are also common. About a third exhibit prodromal psychotic symptoms and our longitudinal studies indicate these are more likely to be present in those with specific cognitive deficits and mental health symptoms at baseline. Our population-based studies indicate that older age individuals with these genetic variants are at higher risk of internalising and cardiometabolic conditions and physical and mental health multimorbidity. Improvements in early referral for genetic testing and timely provision of mental health support could reduce adverse outcomes throughout the lifespan.

Speakers

Professor Marianne van den Bree, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University

Availability

This webinar is part of the Congress 2025 webinar library package which is no longer available for purchase. If your Congress Webinar Library 2025 subscription is still active, you can still watch this webinar.