Overview
This symposium will provide an up-to-date review of the inter-relationships between sleep, circadian rhythms and mental health, with a focus on new research and clinically-relevant material.
Three talks will be as follows:
Dr Amber Roguski, University of Edinburgh, will present an analysis of metabolic and psychiatric data from the UK Biobank cohort in her talk 'Seasonal variation of diabetic markers in bipolar disorder.' This will include a consideration of the clinical relevance of seasonal changes in bipolar disorder.
Professor Matt Jones, University of Bristol, will speak on 'Sleep detectives: stratifying the circuity of disordered cognition through the lens of sleep.' This presentation will cover research on neurophysiology in rodents and scalp EEG in humans, particularly young people with 22q11.2 deletion syndrome. We will make the case that integrating sleep neurophysiology into translational psychiatry can expedite our understanding of the subjective experience and unique neurobiology of individual patients.
Professor Daniel Smith, University of Edinburgh, will speak on 'The light hypersensitivity hypothesis of bipolar disorder: implications for treatment.' This presentation will critically review the evidence for light hypersensitivity in bipolar disorder and discuss how this may shape future research and clinical innovation.
Objectives
- An understanding of how light synchronises sleep and circadian rhythms and why this is particularly important in bipolar disorder.
- New knowledge on a novel proposed mechanism of action of lithium therapy.
- Understanding cross-sectional and longitudinal associations of sleep and circadian disruption with depression risk.
- Understanding links between sleep/circadian disruption and depression and their interaction on measures of brain structure.
- Understanding transdiagnostic features of sleep neurophysiology.
- Understanding how non-REM EEG reflects neural circuit development, function and dysfunction.
- Understanding how to integrate longitudinal subjective and objective measures of sleep health.
Speakers
Chair: Professor Daniel Smith, The University of Edinburgh, Edinburgh
Dr Amber Roguski, The University of Edinburgh, Edinburgh
Professor Matt Jones, University of Bristol, Bristol
Professor Daniel Smith, The University of Edinburgh, Edinburgh
